Download Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), by Taotao Zou PDF

By Taotao Zou

This thesis specializes in the improvement of gold- and non-classical platinum-based anti-cancer brokers that reveal distinctively diversified anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are capable of shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. distinct chemical synthesis, in vitro and/or in vivo anti-cancer actions are sincerely offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) advanced with a combined diphosphine and bis(NHC) ligand exhibiting favorable balance and exhibiting major inhibition of tumor development in self reliant mice versions with out observable unwanted side effects; and (iii) a panel of solid luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and cellphone apoptosis. those works spotlight the medical strength that gold and platinum complexes supply for melanoma treatment.

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